Works great and the software is still available on Logitech's site. Asking $20.
Your Harmony 650 allows you merge the remotes of up to 8 of your home entertainment devices into one so you can, and should! keep those other remotes out of sight.
The Harmony software will guide you through entering the manufacturer and model numbers of your home devices so Harmony understands how to control them. It then helps you create Activities (or scenes) so you're only one-button away from watching television or playing a game.